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Diphenidine

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Diphenidine  (1,2-DEP, DPD, DND) is a dissociative anesthetic that has been sold as a designer drug. The synthesis of diphenidine was first reported in 1924, and employed a Bruylants reaction analogous to the one that would later be used to

Description

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Diphenidine  (1,2-DEP, DPD, DND) is a dissociative anesthetic that has been sold as a designer drug. The synthesis of diphenidine was first reported in 1924, and employed a Bruylants reaction analogous to the one that would later be used to  Diphenidinediscover phencyclidine in 1956. Shortly after the 2013 UK ban on arylcyclohexylamines, diphenidine and the related compound methoxphenidine became available on the grey market. Anecdotal reports describe high doses of it producing  bizarre somatosensory phenomena and transient anterograde amnesia.  Diphenidine and related diarylethylamines have been studied in vitro as treatments for neurotoxic injury and are antagonists of the NMDA receptor.  In dogs diphenidine exhibits greater antitussive potency than codeine phosphate.
Vendors claim that due to the nature of chemical structure, substance should be comparable to other NMDA antagonists such as ketamine. It‘s also said that it acts as an antagonist at the NMDA receptor and as dopamine reuptake inhibitor.

​Side Effects Diphenidine

There are several reports of its effects. Here‘s short summary of them:​
60 mg insufflated gave a high similar to pre-hole MXE doses, with a mood lift and glow lasting for 3 hours. Other user compared 60 mg (insufflated) with low doses of MXE and 3-meo-PCP. While another user was interested with the dissociative effects, but claimed that they are really different from other hexylamines, lacks the introspection, fragmented thoughts. Lastly, while 100mg orally was mentioned as weak experience, 150 mg orally was described as “journey to Jupiter and beyond”.
 Onset usually takes 30-60 minutes. Increases heartrate. Lacks the pleasant dopamine rush that several other dissociatives have. Oral route is recommended. Trip sitter recommended, as compound erases memory at doses above 150 mg. Less physically disabling than methoxetamine. ​
Chemical and physical properties of it include a heavy atom count of 23, topological polar surface area of 23.5, covalently bonded unit count of 1, feature 3D acceptor count of 1, 3D donor count of 1, feature cation count of 1, feature 3D ring count of 3, and effective rotor count of 4.2.http://tafpharmacyglobal.com/

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